Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations.
نویسندگان
چکیده
MYC translocations represent a genetic subtype of T-lineage acute lymphoblastic leukemia (T-ALL), which occurs at an incidence of ∼6%, assessed within a cohort of 196 T-ALL patients (64 adults and 132 children). The translocations were of 2 types; those rearranged with the T-cell receptor loci and those with other partners. MYC translocations were significantly associated with the TAL/LMO subtype of T-ALL (P = .018) and trisomies 6 (P < .001) and 7 (P < .001). Within the TAL/LMO subtype, gene expression profiling identified 148 differentially expressed genes between patients with and without MYC translocations; specifically, 77 were upregulated and 71 downregulated in those with MYC translocations. The poor prognostic marker, CD44, was among the upregulated genes. MYC translocations occurred as secondary abnormalities, present in subclones in one-half of the cases. Longitudinal studies indicated an association with induction failure and relapse.
منابع مشابه
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word count: 131; Text word count: 1196 26 References: 25; Table: 1; Figure: 1 27 28 Blood First Edition Paper, prepublished online September 30, 2014; DOI 10.1182/blood-2014-06-578856 Copyright © 2014 American Society of Hematology For personal use only. on October 28, 2017. by guest www.bloodjournal.org From
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عنوان ژورنال:
- Blood
دوره 124 24 شماره
صفحات -
تاریخ انتشار 2014